UNIVERSITY OPHTHALMOLOGY CONSULTANTS
 

CASE OF THE MONTH

CASE #19

 
ADVERSE EFECTS OF PRESCRIBED MEDICATIONS
 MEDICATION      RELEVANT ADVERSE REACTIONS
   
Cyclosporine
  • glomerular capillary thrombosis with pathological changes resembling hemolytic-uremic syndrome
  • thrombosis of the renal microvasculature with platelet-fibrin thrombi occluding glomerular capillaries and afferent arterioles
  • microangiopathic hemolytic anemia
  • thrombocytopenia
  • hypertension
  • viral infections
  • hepatotoxicity
  • leukopenia
  • lymphoma
  • septicemia
  • systemic and/or local fungal infections
  • abcesses
  • peripheral ischemia
  • herpes zoster
  • herpes simplex
  • bacterial infections
  • moniliasis
  • hyperuricemia
  • diabetes mellitus
  • cataract
  • conjunctivitis
  • eye pain.
   
Prednisone
  • may enhance secondary ocular infections due to fungi or viruses
  • hypertension
  • ecchymosis
  • imparied wound healing
  • pseudotumor cerebri
  • cataract
  • increased intraocular pressure
  • diabetes mellitus
  • increased intraocular pressure
   
Glucagon
  • hypoglycemia in the presence of insulinoma
  • hypertension in the presence of pheochromocytoma
   
Amlodipine besylate
  • vasodilation
  • conjunctivitis
  • diplopia
  • eye pain
  • abnormal visual accomodation
  • xerophthalmia
   
Pravastatin
  • CNS vascular lesions characterized by perivascular hemorrhages and edema in animal studies
  • a chemically similar drug in this class produced optic nerve degeneration
  • retinal gangion cell chromatolysis in animal studies
  • progression of cataracts
  • ophthalmoplegia
   
Trimethoprim / Sulfamethoxazole
  • photosensitivity
  • conjunctival and scleral injection
  • pancreatitis
   
Acyclovir / Ganciclovir
  • visual abnormalities
   
Mycophenolate mofetil
  • leukocytosis
  • increase in certain types of infection
  • ecchymosis
  • peripheral vascular disease
  • thrombosis
  • vasodilation
  • hypercholesterolemia
  • hemorrhage
  • conjunctivitis
  • cataract
  • amblyopia
   
Temaxepam
  • horizontal nystagmus
  • blurred vision
   
Furosemide
  • systemic vasculitis
  • necrotizing angiitis (both of which are systemic hypersensitivity reactions)
  • blurred vision
   
Digoxin
  • visual disturbances with blurred or yellow vision
   
Niacin
  • toxic amblyopia
  • cystoid macular edema
   
Tamsulosin
  • orthostatic hypotension
   
Alodrenate sodium
  • no known relevant adverse reactions
   
Aspirin
  • bleeding
   
Simulect (basiliximab)
  • hypercholesterolemia
  • viral infection
  • sepsis
  • aggravated hypertension
  • hypotension
  • arrhythmia
  • atrial fibrillation
  • diabetes mellitus
  • hemorrhage
  • thrombocytopenia
  • thrombosis
  • polycythemia
  • herpes simplex
  • herpes zoster
  • vascular disorder
  • cataract
  • conjunctivits
  • infection
   
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