• Almost
exclusively in adults
• Continuum
incl benign reactive lymphoid hyperplasia (pseudolymphoma)
to atypical lymphoid hyperplasia to low-grade
then high-grade malignant lymphoma; also OIS/pseudotumor/plasmacytoma
(incl myeloma)
• Bimodal
peak 30s and 60s
• Unilateral
or bilateral
• Palpable
rubbery mass fixed to rim
• Malig
lymphoma & atypical lymphoid hyperplasia cause gradual
(over a year or more) progressive, painless proptosis
(vs OIS), lacrimal enlargement (50 % of orbital lymphoproliferative
lesions involve lacrimal gland)
• Often
on conjunctiva, anterior orbit, so palpable or visible
• Eyelid
or bilateral orbital involvement more often associated
with systemic disease
